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KMID : 0378019600030070055
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New Medical Journal
1960 Volume.3 No. 7 p.55 ~ p.72
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Experimental Studies on the Influences of R. E. S. Blockade on Allergic Changes in the Kidney
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Abstract
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Since it has been postulated that reticulo-endothelial system may give the influences to allergic reaction, various investigation on R.E.S, have beconme as a target subject to clarify the mechanism of allergic phenomenon.
Some investigators suggested that R.E.S. are closely related to the productien of antibody, as they found the inhibition of anaphylactic shock in R.E S. blockade animal, experimentally. Yet enhancement of anaphylactic shock in R.E.S.
blockade with small amount of I idia ink to the experimental animals is reported by llaendel and Kare Ue. Prof. Yun described the existence of inhibitory substance against anaphylactic shock in the animal serum of R.E.S. blockade.
Marked inhibition of allergic changes in various organ of R.E.S. blockaded animal, in both small
and large amount of India ink administrantion, is reported.
This experiment has been planned to study the influences of R.E.S. upon the allergic changes in the kidney.
ExperimentaI Material and Methods
Normal adult rabbits weighing around 2 kilograms were used for this experiment and divided into 6 groups.
For sensitizing, lcc. of normal horse seum per kg. of body weight was injected subcutaneously 4times, and O.lec. of normal horse serum per kg. of body weight was reinjected for producing allergic changes in tissue.
For blockading the R.E.S., 0.43% of India ink in saline solution was injected intravenously.
1) Control
Asa control experiment, allergic changes were observed in rabbits in which noraml serum was injected subcutaneously four times for sensitizing, and for reinjection 0.1 cc. per kg. of body weight of normal horse serum was given locally in kidney through the´renal artery, two weeks later. The allergic changes in the kidney were observed.
2) Single injection of India ink solution
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